Neu(ronal) custodians of cutaneous immunity

Kody Paul Mansfield; Shruti Naik

doi:10.1016/j.cell.2021.03.040

Neu(ronal) custodians of cutaneous immunity

Cell. 2021 Apr 15;184(8):1968-1970. doi: 10.1016/j.cell.2021.03.040.

Authors

Kody Paul Mansfield¹, Shruti Naik²

Affiliations

¹ Department of Pathology, Department of Medicine, Ronald O. Perelman Department of Dermatology and Perlmutter Cancer Center, New York University Langone Health, 550 First Avenue, New York, NY 10016, USA.
² Department of Pathology, Department of Medicine, Ronald O. Perelman Department of Dermatology and Perlmutter Cancer Center, New York University Langone Health, 550 First Avenue, New York, NY 10016, USA. Electronic address: [email protected].

PMID: 33861962
DOI: 10.1016/j.cell.2021.03.040

Abstract

Sensory neurons have surfaced as key instigators of skin inflammation. In this issue of Cell, Zhang et al. define an anti-inflammatory Langerhans cell (LC)-neuron-mast cell (MC) circuit that underlies skin immune homeostasis. They uncover a role for LCs in maintaining innervation of MrgprD⁺ nonpeptidergic neurons that restrain MC activation via glutamate secretion.

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MeSH terms

Homeostasis
Langerhans Cells*
Mast Cells
Sensory Receptor Cells
Skin*