β-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery

Parbeen Singh; Yongli Chen; Deependra Tyagi; Li Wu; Xiaohong Ren; Jinglong Feng; Andrew Carrier; Tiangang Luan; Yongjun Tang; Jiwen Zhang; Xu Zhang

doi:10.1016/j.ijpharm.2021.120602

β-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery

Int J Pharm. 2021 Jun 1:602:120602. doi: 10.1016/j.ijpharm.2021.120602. Epub 2021 Apr 20.

Authors

Parbeen Singh¹, Yongli Chen², Deependra Tyagi³, Li Wu⁴, Xiaohong Ren⁴, Jinglong Feng⁵, Andrew Carrier⁶, Tiangang Luan⁷, Yongjun Tang⁸, Jiwen Zhang⁹, Xu Zhang¹⁰

Affiliations

¹ Postdoctoral Innovation Practice Base, Department of Biological Applied Engineering, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China; State Key Laboratory Biocontrol, School of Marine Sciences, Sun Yat-sen University, Guangzhou 51027, China; Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
² Postdoctoral Innovation Practice Base, Department of Biological Applied Engineering, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China; State Key Laboratory Biocontrol, School of Marine Sciences, Sun Yat-sen University, Guangzhou 51027, China.
³ School of Basic Medical Sciences, School of Medicine, Shenzhen University, Shenzhen, Guangdong 518060, China.
⁴ Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
⁵ Postdoctoral Innovation Practice Base, Department of Biological Applied Engineering, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China.
⁶ Department of Chemistry and Department of Health Sciences, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia B1P 6L2, Canada.
⁷ State Key Laboratory Biocontrol, School of Marine Sciences, Sun Yat-sen University, Guangzhou 51027, China.
⁸ Postdoctoral Innovation Practice Base, Department of Biological Applied Engineering, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China. Electronic address: [email protected].
⁹ Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, National Institutes for Food and Drug Control, No.2 Tiantan Xili, Beijing 100050, China. Electronic address: [email protected].
¹⁰ Department of Chemistry and Department of Health Sciences, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia B1P 6L2, Canada. Electronic address: [email protected].

PMID: 33862128
DOI: 10.1016/j.ijpharm.2021.120602

Abstract

β-Cyclodextrin (β-CD) was grafted onto hyaluronic acid (HA) in a single step to generate a supramolecular biopolymer (HA-β-CD) that was explored for targeted drug delivery applications. Along with its excellent biocompatibility, the prepared HA-β-CD exhibits not only exceptionally high loading capacity for the model drugs doxorubicin and Rhodamine B through the formation of inclusion complexes with the β-CD component, but also the capability of targeted drug delivery to cancerous cells with a high level of expression of CD44 receptors, attributable to its HA component. The polymer can release the drug under slightly acidic conditions. With all its attributes, HA-β-CD may be a promising cancer-cell-targeting drug carrier.

Keywords: Hyaluronic acid-cyclodextrin; Supramolecular polymer; Targeted drug delivery; pH-responsive drug release.

MeSH terms

Doxorubicin
Drug Carriers
Drug Delivery Systems
Hyaluronic Acid*
beta-Cyclodextrins*

Substances

Drug Carriers
beta-Cyclodextrins
Doxorubicin
Hyaluronic Acid