Perivascular Macrophages Regulate Blood Flow Following Tissue Damage

Circ Res. 2021 May 28;128(11):1694-1707. doi: 10.1161/CIRCRESAHA.120.318380. Epub 2021 Apr 21.

Authors

Evelina Vågesjö^#¹, Kristel Parv^#¹, David Ahl^#¹, Cédric Seignez¹, Carmen Herrera Hidalgo¹, Antoine Giraud¹, Catarina Leite¹, Olle Korsgren², Håkan Wallén³, Greta Juusola⁴, Harri H Hakovirta⁵, Helene Rundqvist⁶, Magnus Essand², Lena Holm¹, Randall S Johnson^{6

7}, Charlotte Thålin³, Petra Korpisalo⁸, Gustaf Christoffersson^{1

9}, Mia Phillipson^{1

9}

Affiliations

¹ Medical Cell Biology (E.V., K.P., D.A., C.S., C.H.H., A.G., C.L., L.H., G.C., M.P.), Uppsala University, Sweden.
² Immunology, Genetics and Pathology (O.K., M.E.), Uppsala University, Sweden.
³ Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden (H.W., C.T.).
⁴ A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland (G.J.).
⁵ Department of Vascular Surgery, Turku University Hospital, Finland (H.H.H.).
⁶ Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (H.R., R.S.J.).
⁷ Physiology, Development and Neuroscience, University of Cambridge, United Kingdom (R.S.J.).
⁸ Heart Center, Kuopio University Hospital, Finland (P.K.).
⁹ The Science for Life Laboratory (G.C., M.P.), Uppsala University, Sweden.

^# Contributed equally.

PMID: 33878889
DOI: 10.1161/CIRCRESAHA.120.318380

Abstract

[Figure: see text].

Keywords: ischemia; morbidity; perfusion; peripheral artery disease; plasmids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Movement
Cell Proliferation
Chemokine CCL2 / metabolism
Chemokine CXCL12 / metabolism*
Humans
Ischemia / physiopathology
Ischemia / therapy*
Macrophages / cytology
Macrophages / metabolism
Macrophages / physiology*
Mice
Muscle, Skeletal / blood supply*
Nitric Oxide / metabolism
Nitric Oxide Synthase Type II / deficiency
Nitric Oxide Synthase Type II / metabolism*
Nitric Oxide Synthase Type III / metabolism
Plasmids / metabolism
Receptors, CCR2 / metabolism
Receptors, CXCR4 / metabolism
Regional Blood Flow / physiology*

Substances

Chemokine CCL2
Chemokine CXCL12
Receptors, CCR2
Receptors, CXCR4
Nitric Oxide
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III