A Case of Severe Acute Respiratory Syndrome Coronavirus 2 Treatment With Remdesivir in a Hepatitis C-Coinfected Patient Resulting in Temporary Viral Control and Posttreatment Flare

Maria Ribeiro da Cunha; Inês Coelho Rodrigues; Frederico Trigueiros; Luís Carlos Freitas; Sandra Braz; Fábio Cota Medeiros

doi:10.1093/ofid/ofab100

A Case of Severe Acute Respiratory Syndrome Coronavirus 2 Treatment With Remdesivir in a Hepatitis C-Coinfected Patient Resulting in Temporary Viral Control and Posttreatment Flare

Open Forum Infect Dis. 2021 Mar 2;8(4):ofab100. doi: 10.1093/ofid/ofab100. eCollection 2021 Apr.

Authors

Maria Ribeiro da Cunha¹, Inês Coelho Rodrigues², Frederico Trigueiros³, Luís Carlos Freitas², Sandra Braz³, Fábio Cota Medeiros¹

Affiliations

¹ Department of Infectious Diseases at the Santa Maria Hospital, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.
² Department of Gastroenterology at the Santa Maria Hospital, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.
³ Department of Internal Medicine at the Santa Maria Hospital, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.

Abstract

We report a case of a man with chronic hepatitis C infection treated with remdesivir for COVID-19, resulting in lowered HCV viral load, followed by a rebound after its discontinuation. Concomitant treatment with tocilizumab possibly caused loss of anti-HBs.

Keywords: COVID-19; anti-HBs; hepatitis B; hepatitis C; remdesivir.