Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism

Circ Res. 2021 Jun 25;129(1):9-29. doi: 10.1161/CIRCRESAHA.120.318805. Epub 2021 Apr 23.

Abstract

[Figure: see text].

Keywords: endothelial cells; glucose; glycolysis; inflammation; mitochondria.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Coculture Techniques
  • Endothelial Cells / drug effects*
  • Endothelial Cells / immunology
  • Endothelial Cells / metabolism
  • Energy Metabolism / drug effects*
  • Gene Expression Regulation
  • Glucose / metabolism*
  • Glycolysis / drug effects
  • Humans
  • Inflammation / genetics
  • Inflammation / immunology
  • Inflammation / metabolism*
  • Inflammation Mediators / metabolism*
  • Kinetics
  • Leukocyte Rolling / drug effects
  • Leukocytes / drug effects*
  • Leukocytes / immunology
  • Leukocytes / metabolism
  • Lipopolysaccharides / pharmacology*
  • Male
  • Metabolome*
  • Metabolomics
  • Mice
  • Mice, Inbred C57BL
  • Oxidative Phosphorylation / drug effects
  • Phenotype
  • THP-1 Cells
  • Tumor Necrosis Factor-alpha / pharmacology*

Substances

  • Inflammation Mediators
  • Lipopolysaccharides
  • TNF protein, human
  • Tumor Necrosis Factor-alpha
  • lipopolysaccharide, Escherichia coli O111 B4
  • Glucose