Exploring the Alternative Splicing of Long Noncoding RNAs

Muhammad Riaz Khan; Raymund J Wellinger; Benoit Laurent

doi:10.1016/j.tig.2021.03.010

Exploring the Alternative Splicing of Long Noncoding RNAs

Trends Genet. 2021 Aug;37(8):695-698. doi: 10.1016/j.tig.2021.03.010. Epub 2021 Apr 21.

Authors

Muhammad Riaz Khan¹, Raymund J Wellinger², Benoit Laurent³

Affiliations

¹ Research Center on Aging, Centre Intégré Universitaire de Santé et Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada; Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
² Research Center on Aging, Centre Intégré Universitaire de Santé et Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada; Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
³ Research Center on Aging, Centre Intégré Universitaire de Santé et Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada; Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada. Electronic address: [email protected].

PMID: 33892960
DOI: 10.1016/j.tig.2021.03.010

Abstract

Like protein-coding genes, long noncoding RNA (lncRNA) genes are composed of introns and exons. After their transcription, lncRNAs are subject to constitutive and/or alternative splicing. Here, we describe the current knowledge on lncRNA splice variants and their functional implications in cell biology.

Keywords: alternative splicing; long noncoding RNA; splice variant.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alternative Splicing / genetics*
DNA, Recombinant / genetics*
Exons / genetics
Introns / genetics
RNA, Long Noncoding / genetics*

Substances

DNA, Recombinant
RNA, Long Noncoding