Functional Immunostimulating DNA Materials: The Rising Stars for Cancer Immunotherapy

Ziwen Dai; Lei Wang; Zhigang Wang

doi:10.1002/mabi.202100083

Functional Immunostimulating DNA Materials: The Rising Stars for Cancer Immunotherapy

Macromol Biosci. 2021 Jun;21(6):e2100083. doi: 10.1002/mabi.202100083. Epub 2021 Apr 25.

Authors

Ziwen Dai^{1

2}, Lei Wang¹, Zhigang Wang³

Affiliations

¹ College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518055, China.
² Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
³ School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518055, China.

PMID: 33896107
DOI: 10.1002/mabi.202100083

Abstract

Cancer immunotherapy has risen as a promising method in clinical practice for cancer treatment and DNA-based immune intervention materials, along with DNA nanotechnology, have obtained increasing importance in this field. In this review, various immunostimulating DNA materials are introduced and the mechanisms via which they exerted an immune effect are explained. Then, representative examples in which DNA is used as the leading component for anticancer applications through immune stimulation are provided and their efficacy is evaluated. Finally, the challenges for those materials in clinical applications are discussed and suggestions for possible further research directions are also put forward.

Keywords: DNA materials; anticancer therapy; immunology.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antibodies, Monoclonal / biosynthesis
Antibodies, Monoclonal / genetics
Antibodies, Monoclonal / therapeutic use
Aptamers, Nucleotide / genetics
Aptamers, Nucleotide / immunology
Aptamers, Nucleotide / therapeutic use*
B7-H1 Antigen / antagonists & inhibitors*
B7-H1 Antigen / genetics
B7-H1 Antigen / immunology
Dinucleotide Repeats / genetics
Dinucleotide Repeats / immunology
Gene Expression Regulation, Neoplastic
Humans
Immune Checkpoint Inhibitors / chemical synthesis
Immune Checkpoint Inhibitors / metabolism
Immune Checkpoint Inhibitors / therapeutic use*
Immunization / methods
Immunotherapy / methods*
Nanomedicine / methods
Nanoparticles / administration & dosage
Nanoparticles / chemistry
Neoplasms / genetics
Neoplasms / immunology
Neoplasms / pathology
Neoplasms / therapy*
Programmed Cell Death 1 Receptor / antagonists & inhibitors*
Programmed Cell Death 1 Receptor / genetics
Programmed Cell Death 1 Receptor / immunology
Signal Transduction
Toll-Like Receptor 9 / antagonists & inhibitors*
Toll-Like Receptor 9 / genetics
Toll-Like Receptor 9 / immunology
Tumor Microenvironment / drug effects

Substances

Antibodies, Monoclonal
Aptamers, Nucleotide
B7-H1 Antigen
CD274 protein, human
Immune Checkpoint Inhibitors
PDCD1 protein, human
Programmed Cell Death 1 Receptor
TLR9 protein, human
Toll-Like Receptor 9