Role of Vitamin D and Vitamin D Receptor in Oral Lichen Planus: A Systematic Review

Paria Motahari; Fatemeh Pournaghi Azar; Arefeh Rasi

doi:10.4314/ejhs.v30i4.17

Role of Vitamin D and Vitamin D Receptor in Oral Lichen Planus: A Systematic Review

Ethiop J Health Sci. 2020 Jul 1;30(4):615-622. doi: 10.4314/ejhs.v30i4.17.

Authors

Paria Motahari¹, Fatemeh Pournaghi Azar², Arefeh Rasi³

Affiliations

¹ Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
² Assistant Professor, Department of Restorative Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Dentist, Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Background: Oral lichen planus (OLP) is known to be a chronic inflammatory disease associated with various other systemic disorders. Studies have shown that vitamin D deficiency can be involved in the pathogenesis of lichen planus. The aim of this study was to investigate the role of vitamin D and vitamin D receptor in OLP.

Methods: In this review study, all English and Persian articles were searched by relevant keywords from the Google scholar, PubMed, science direct, Cochrane, Scopus and Sid databases until January 2020.

Results: From the 16 articles obtained after reviewing the abstracts, finally 14 appropriate articles were included in this study.

Conclusion: According to the results of the studies, vitamin D deficiency may be associated with an increased risk of OLP lesions.

Keywords: Oral lichen planus; Vitamin D; Vitamin D receptor.

Publication types

Systematic Review

MeSH terms

Chronic Disease
Humans
Lichen Planus, Oral*
Receptors, Calcitriol*
Vitamin D Deficiency*
Vitamin D*

Substances

Receptors, Calcitriol
Vitamin D