Effectiveness of daptomycin against infective endocarditis caused by highly penicillin-resistant viridans group streptococci

Takahiro Matsuo; Nobuyoshi Mori; Aki Sakurai; Takayoshi Kanie; Yumiko Mikami; Yuki Uehara; Keiichi Furukawa

doi:10.1016/j.idcr.2021.e01113

Effectiveness of daptomycin against infective endocarditis caused by highly penicillin-resistant viridans group streptococci

IDCases. 2021 Apr 5:24:e01113. doi: 10.1016/j.idcr.2021.e01113. eCollection 2021.

Authors

Takahiro Matsuo¹, Nobuyoshi Mori¹, Aki Sakurai¹, Takayoshi Kanie², Yumiko Mikami³, Yuki Uehara^{1

3

4

5}, Keiichi Furukawa¹

Affiliations

¹ Department of Infectious Diseases, St. Luke's International Hospital, Tokyo, Japan.
² Department of Cardiology, St. Luke's International Hospital, Tokyo, Japan.
³ Department of Clinical Laboratory, St. Luke's International Hospital, Tokyo, Japan.
⁴ Department of Microbiology, Juntendo University Faculty of Medicine, Tokyo, Japan.
⁵ Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

Abstract

Penicillin-resistant viridans group streptococci (VGS) infections are an emerging issue in infectious diseases. Here, we present a case of mitral valve infective endocarditis caused by highly penicillin-resistant VGS (minimum inhibitory concentration >4 μg/mL), which was successfully treated with daptomycin. Although the clinical efficacy of daptomycin has not been established, it can be an alternative for the treatment of highly resistant VGS endocarditis.

Keywords: Daptomycin; Infective endocarditis; Penicillin-resistant viridans group streptococci.

Publication types

Case Reports