cAMP Imaging at Ryanodine Receptors Reveals β2-Adrenoceptor Driven Arrhythmias

cAMP Imaging at Ryanodine Receptors Reveals β₂-Adrenoceptor Driven Arrhythmias

Circ Res. 2021 Jun 25;129(1):81-94. doi: 10.1161/CIRCRESAHA.120.318234. Epub 2021 Apr 27.

Filip Berisha^{1

2

3}, Konrad R Götz⁴, Jörg W Wegener^{4

5}, Sören Brandenburg^{4

5}, Hariharan Subramanian^{1

3}, Cristina E Molina^{1

3}, André Rüffer⁶, Johannes Petersen⁶, Alexander Bernhardt⁶, Evaldas Girdauskas⁶, Christiane Jungen^{2

7}, Ulrike Pape^{2

7}, Axel E Kraft^{1

3}, Svenja Warnke^{2

3}, Diana Lindner^{2

3}, Dirk Westermann^{2

3}, Stefan Blankenberg^{2

3}, Christian Meyer^{2

7}, Gerd Hasenfuß^{4

5}, Stephan E Lehnart⁵, Viacheslav O Nikolaev^{1

3}

¹ Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (F.B., H.S., C.E.M., A.E.K., V.O.N.).
² Department of Cardiology (F.B., C.J., U.P., S.W., D.L., D.W., S. Blankenberg, C.M.), University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
³ DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany (F.B., H.S., C.E.M., A.E., S.W., D.L., D.W., S. Blankenberg, V.O.N.).
⁴ Department of Cardiology and Pulmonology, Heart Research Center Göttingen, Georg August University Medical Center, Germany (K.R.G., J.W.W., S. Brandenburg, G.H., S.E.L.).
⁵ DZHK (German Center for Cardiovascular Research), partner site Göttingen, Germany (J.W.W., S. Brandenburg, G.H., S.E.L.).
⁶ Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Germany (A.R., J.P., A.B., E.G.).
⁷ Department of Cardiology-Electrophysiology, cNEP (Cardiac Neuro- and Electrophysiology Research Group) (C.J., U.P., C.M.), University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

[Figure: see text].

Keywords: cardiomyocyte; heart failure; phosphorylation; receptor, adrenergic; sarcoplasmic reticulum.