Comparison of Outcomes between Obese and Nonobese Patients in Laparoscopic Adrenalectomy: A Cohort Study

Dig Surg. 2021;38(3):237-246. doi: 10.1159/000515589. Epub 2021 Apr 27.

Abstract

Introduction: Obesity is usually considered a risk factor for surgical complications. Laparoscopic adrenalectomy has replaced open adrenalectomy as the standard operation for adrenal tumors.

Objective: To compare the safety of laparoscopic adrenalectomy to treat adrenal tumors in obese versus nonobese patients.

Methods: This observational cohort study analyzed consecutive patients who underwent laparoscopic adrenalectomy with a lateral transperitoneal approach at a single center (2003-2020). Data and outcomes of obese (body mass index ≥30 kg/m2) and nonobese patients were compared. To analyze the association between operative time and other variables, we used simple and multivariate linear regression.

Results: N = 160 (90 obese/70 nonobese) patients underwent laparoscopic adrenalectomy. Cushing syndrome and pheochromocytoma were the most frequent indications. Obese patients were older (58 vs. 52 years, p < 0.001). A greater proportion of obese patients were ASA grade III + IV (71.1 vs. 48.6%, p = 0.004). Obesity was associated with a longer operative time (72.5 vs. 60 min, p < 0.001) and greater blood loss (40 vs. 20 mL, p = 0.022). There were no differences in conversion, morbidity, or hospital stay. After adjustment for confounding factors, operative time was positively correlated with BMI ≥30 kg/m2, learning curve, estimated blood loss, 2D laparoscopy, and specimen size.

Conclusion: Lateral transperitoneal laparoscopic adrenalectomy is safe in patients with a BMI 30-35 kg/m2, so these patients also benefit from this minimally invasive surgery.

Keywords: Adrenal surgery; Adrenal tumors; Lateral transperitoneal laparoscopic adrenalectomy; Minimally invasive surgery; Obesity.

Publication types

  • Observational Study

MeSH terms

  • Adenoma / complications
  • Adenoma / surgery*
  • Adolescent
  • Adrenal Gland Neoplasms / complications
  • Adrenal Gland Neoplasms / surgery*
  • Adrenalectomy / methods*
  • Adult
  • Aged
  • Blood Loss, Surgical / statistics & numerical data
  • Case-Control Studies
  • Female
  • Humans
  • Laparoscopy*
  • Length of Stay / statistics & numerical data
  • Linear Models
  • Male
  • Middle Aged
  • Obesity / complications*
  • Operative Time
  • Pheochromocytoma / complications
  • Pheochromocytoma / surgery*
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology
  • Prospective Studies
  • Risk Factors
  • Treatment Outcome
  • Young Adult