Three-Component Reactions of 3-Arylidene-3 H-Indolium Salts, Isocyanides and Amines

Hung M Nguyen; Nikita E Golantsov; Alexandra S Golubenkova; Victor B Rybakov; Leonid G Voskressensky

doi:10.3390/molecules26092402

Three-Component Reactions of 3-Arylidene-3 H-Indolium Salts, Isocyanides and Amines

Molecules. 2021 Apr 21;26(9):2402. doi: 10.3390/molecules26092402.

Authors

Hung M Nguyen^{1

2}, Nikita E Golantsov¹, Alexandra S Golubenkova¹, Victor B Rybakov³, Leonid G Voskressensky¹

Affiliations

¹ Department of Organic Chemistry, Faculty of Science, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.
² Faculty of Natural Sciences, Hung Vuong University, Nguyen Tat Thanh Street, Viet Tri 35120, Vietnam.
³ Faculty of Chemistry, Lomonosov Moscow State University, 1-3 Leninskiye Gory, 119991 Moscow, Russia.

Abstract

A multicomponent reaction of isocyanides with aryl(indol-3-yl)methylium salts and amines has been found. A series of aryl(indol-3-yl)acetimidamides was obtained in up to 96% yields. In the case of ethyl isocyanoacetate, the reaction is followed by cyclization to form 3,5-dihydro-4H-imidazol-4-one derivatives.

Keywords: carbenium ions; imidamides; imidazolones; indoles; isocyanides; multicomponent reactions.

Grants and funding

18-73-10057/Russian Science Foundation