Epstein - Barr virus - encoded microRNAs involve in tumorigenesis and development
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Mar 28;46(3):300-308.
doi: 10.11817/j.issn.1672-7347.2021.190744.
[Article in
English,
Chinese]
Affiliations
- 1 Department of Orthopedics, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Guangdong 518000. [email protected].
- 2 Institute of Cancer Research, Central South University, Changsha 410078, China. [email protected].
- 3 Department of Orthopedics, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Guangdong 518000.
- 4 Institute of Cancer Research, Central South University, Changsha 410078, China. [email protected].
Epstein-Barr virus (EBV), a definite tumorigenic virus, is closely related to the development of nasopharyngeal cancer, gastric cancer, lymphoma and other tumors. EBV encodes a total of 44 mature microRNAs, which can regulate the expression of virus and host genes. EBV-encoded microRNAs and their regulated target molecules participate in the biological functions of tumor apoptosis, proliferation, invasion, and metastasis during tumorigenesis and development, and play an important role in the development of tumor.
EB病毒(Epstein-Barr virus，EBV)是一种明确的致瘤性病毒，与鼻咽癌、胃癌、淋巴瘤等多种肿瘤的发生和发展密切相关。EBV共编码44种成熟的微RNA(microRNAs，miRNAs)，可调节病毒自身和宿主基因的表达。EBV编码的miRNAs(Epstein-Barr virus-encoded microRNAs，EBV miRNAs)及其所调控的靶分子参与肿瘤细胞的凋亡、增殖、侵袭和转移等方面的生物学功能，在肿瘤发生和发展过程中发挥重要作用。.
Keywords:
Epstein-Barr virus-encoded microRNAs; epithelial-mesenchymal transition; latent infection; tumor.
MeSH terms
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Carcinogenesis / genetics
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Epstein-Barr Virus Infections* / genetics
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Gene Expression Regulation, Neoplastic
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Herpesvirus 4, Human / genetics
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Humans
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MicroRNAs* / genetics
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Nasopharyngeal Neoplasms* / genetics