Co-dominant neutralizing epitopes make anti-measles immunity resistant to viral evolution

Allison J Greaney; Frances C Welsh; Jesse D Bloom

doi:10.1016/j.xcrm.2021.100257

Co-dominant neutralizing epitopes make anti-measles immunity resistant to viral evolution

Cell Rep Med. 2021 Apr 20;2(4):100257. doi: 10.1016/j.xcrm.2021.100257.

Authors

Allison J Greaney^{1

2}, Frances C Welsh^{1

3}, Jesse D Bloom^{1

4}

Affiliations

¹ Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
² Department of Genome Sciences & Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA.
³ Molecular and Cellular Biology Graduate Program, University of Washington and Fred Hutchinson Cancer Research Center, United States, Seattle, WA 98195, USA.
⁴ Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

Munoz-Alia and colleagues¹ demonstrate that neutralizing antibody immunity to measles resists viral evolutionary escape because it targets numerous distinct viral epitopes. Their work contributes to our understanding of what determines whether a virus can evolve to evade immunity.

Publication types

Comment

MeSH terms

Antibodies, Neutralizing*
Epitopes
Humans
Measles virus / immunology
Measles* / prevention & control

Substances

Antibodies, Neutralizing
Epitopes