Acute ingestion of a high-fructose drink impairs vascular autonomic modulation and reflex control of blood pressure in first-degree relatives of diabetic patients

Diabetes Res Clin Pract. 2021 Jul:177:108793. doi: 10.1016/j.diabres.2021.108793. Epub 2021 May 2.

Abstract

First-degree relatives of diabetes patients, despite being euglycemic, presented impaired BRS and exacerbation of sympathetic modulation after ingestion of a high fructose drink when challenged to orthostatic stress. This finding alerts the importance of early autonomic dysfunction even in clinically healthy people, especially in face of a stressful situation.

Keywords: Autonomic nervous system; Baroreflex; Fructose; Heart rate variability; Type 2 diabetes.

MeSH terms

  • Baroreflex
  • Blood Pressure
  • Diabetes Mellitus* / chemically induced
  • Diabetes Mellitus* / genetics
  • Eating*
  • Fructose / adverse effects
  • Heart Rate
  • Humans
  • Reflex

Substances

  • Fructose