periodicDNA: an R/Bioconductor package to investigate k-mer periodicity in DNA

F1000Res. 2021 Feb 24:10:141. doi: 10.12688/f1000research.51143.1. eCollection 2021.

Abstract

Periodic occurrences of oligonucleotide sequences can impact the physical properties of DNA. For example, DNA bendability is modulated by 10-bp periodic occurrences of WW (W = A/T) dinucleotides. We present periodicDNA, an R package to identify k-mer periodicity and generate continuous tracks of k-mer periodicity over genomic loci of interest, such as regulatory elements. periodicDNA will facilitate investigation and improve understanding of how periodic DNA sequence features impact function.

Keywords: DNA periodicity; gene regulation; promoter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA* / genetics
  • Genome
  • Genomics*
  • Sequence Analysis, DNA

Substances

  • DNA