Rare and fatal complication of immune checkpoint inhibition: a case report of haemophagocytic lymphohistiocytosis with severe lichenoid dermatitis

Br J Haematol. 2021 Jun;193(6):e44-e47. doi: 10.1111/bjh.17442. Epub 2021 May 5.
No abstract available

Keywords: KSHV/HHV8; Kaposi sarcoma; PD-1; haemophagocytic lymphohistiocytosis; immunotherapy; late effects of therapy.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged, 80 and over
  • Drug Eruptions* / metabolism
  • Drug Eruptions* / pathology
  • Fatal Outcome
  • Herpesvirus 8, Human / metabolism*
  • Humans
  • Immune Checkpoint Inhibitors / administration & dosage
  • Immune Checkpoint Inhibitors / adverse effects*
  • Lichenoid Eruptions* / chemically induced
  • Lichenoid Eruptions* / metabolism
  • Lichenoid Eruptions* / pathology
  • Lymphohistiocytosis, Hemophagocytic* / chemically induced
  • Lymphohistiocytosis, Hemophagocytic* / metabolism
  • Lymphohistiocytosis, Hemophagocytic* / pathology
  • Male
  • Neoplasm Proteins / antagonists & inhibitors
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors
  • Sarcoma, Kaposi* / drug therapy
  • Sarcoma, Kaposi* / metabolism
  • Sarcoma, Kaposi* / pathology
  • Severity of Illness Index

Substances

  • Immune Checkpoint Inhibitors
  • Neoplasm Proteins
  • PDCD1 protein, human
  • Programmed Cell Death 1 Receptor