Premenstrual dysphoric symptoms and lifetime suicide experiences in patients with mood disorder

Jen-Hui Chan; Chen Lo; Cheng-Dien Hsu; Chih-Chiang Chiu; Ming-Chyi Huang; Shih-Cheng Liao; I-Ming Chen; Wen-Yin Chen; Hsi-Chung Chen; Po-Hsiu Kuo

doi:10.1016/j.genhosppsych.2021.04.009

Premenstrual dysphoric symptoms and lifetime suicide experiences in patients with mood disorder

Gen Hosp Psychiatry. 2021 Jul-Aug:71:82-87. doi: 10.1016/j.genhosppsych.2021.04.009. Epub 2021 May 1.

Authors

Affiliations

¹ Department of Psychiatry, National Taiwan University Hospital Hsin-Chu Branch, No.25, Lane 442, Sec.1, Jingguo Rd., Hsinchu City 300, Taiwan.
² Department of Psychiatry, National Taiwan University Hospital, No.7 Chung San South Road, Taipei 10002, Taiwan.
³ Department of Psychosomatic Medicine, Taiwan Adventist Hospital, No.424, Sec. 2, Bade Rd., Songshan District, Taipei City 10556, Taiwan.
⁴ Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, No. 309, Songde Rd., Xinyi Dist., Taipei City 110, Taiwan; Department of Psychiatry, School of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei City 110, Taiwan.
⁵ Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, No. 309, Songde Rd., Xinyi Dist., Taipei City 110, Taiwan.
⁶ Department of Psychiatry, National Taiwan University Hospital, No.7 Chung San South Road, Taipei 10002, Taiwan; Department of Psychiatry, National Taiwan University Medical College, No.1 Jen Ai road section 1, Taipei 100233, Taiwan.
⁷ Department of Psychiatry, National Taiwan University Hospital, No.7 Chung San South Road, Taipei 10002, Taiwan. Electronic address: [email protected].
⁸ Department of Psychiatry, National Taiwan University Hospital, No.7 Chung San South Road, Taipei 10002, Taiwan; Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17 Xuzhou Road, Taipei 100, Taiwan.

PMID: 33965699
DOI: 10.1016/j.genhosppsych.2021.04.009

Abstract

Background: Premenstrual dysphoric symptoms (PMDS) commonly co-occurred with mood disorders and correlated with suicide experiences in women. This study aims to examine the associations between PMDS and lifetime suicide experiences in patients with mood disorders.

Methods: Participants were recruited from outpatient settings of two medical centers and one psychiatric hospital in Taiwan. Women aged 18-65 in non-acute state of major depressive disorder or bipolar affective disorder were recruited. PMDS and lifetime suicide experiences were defined by the Schedule for Affective Disorder and Schizophrenia-Lifetime. Lifetime suicide experiences were defined as no suicide experience, suicide plans only and suicide attempts.

Results: A total of 383 women participated in this study (54.8% of them were diagnosed with major depressive disorder), and 13.8% were diagnosed with PMDS. The prevalence of patients with lifetime suicide plans only and lifetime suicide attempts were 15.9% and 39.7%, respectively. In the univariate analysis, PMDS was correlated with lifetime suicide experience. After controlling for covariates, PMDS was a risk indicator for lifetime suicide attempts (OR: 3.46, 95% CI: 1.43-8.38) but not for suicide plans only (OR: 0.93, 95% CI: 0.28-3.11).

Conclusions: PMDS correlated with lifetime suicide experiences in women with non-acute mood disorders. In particular, PMDS exhibited as an independent correlate for lifetime suicide attempts.

Keywords: Lifetime suicide attempts; Lifetime suicide plans; Mood disorders; Premenstrual dysphoric symptoms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bipolar Disorder* / epidemiology
Depressive Disorder, Major* / epidemiology
Female
Humans
Mood Disorders / epidemiology
Premenstrual Dysphoric Disorder*
Schizophrenia*
Suicide, Attempted