In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism

Hypertension. 2021 Jul;78(1):128-137. doi: 10.1161/HYPERTENSIONAHA.121.17164. Epub 2021 May 10.

Giannie Barsha^#^{1

2}, Katrina M Mirabito Colafella^#^{1

2}, Sarah L Walton^{1

2}, Tracey A Gaspari^{1

3}, Iresha Spizzo^{1

3}, Anita A Pinar^{1

3}, Lucinda M Hilliard Krause^{1

2}, Robert E Widdop^{1

3}, Chrishan S Samuel^{1

3}, Kate M Denton^{1

2}

¹ Cardiovascular Disease Program, Monash Biomedicine Discovery Institute (G.B., K.M.M.C., S.L.W., T.A.G., I.S., A.A.P., L.M.H.K., R.E.W., C.S.S., K.M.D.), Monash University, Melbourne, Victoria, Australia.
² Department of Physiology (G.B., KM.M.C., S.L.W., L.M.H.K., K.M.D.), Monash University, Melbourne, Victoria, Australia.
³ Department of Pharmacology (T.A.G., I.S., A.A.P., R.E.W., C.S.S.), Monash University, Melbourne, Victoria, Australia.

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: aging; angiotensin II; cardiovascular disease; endothelium; menopause.