Shining light on the neuro-immune axis in the gut

Immunity. 2021 May 11;54(5):850-852. doi: 10.1016/j.immuni.2021.04.016.

Abstract

In this issue of Immunity, Schiller et al. report that local sympathetic nerve activation decreases endothelial expression of the adhesion molecule MAdCAM-1, reducing immune cell infiltration and colitis-induced inflammation. These findings suggest that local sympathetic stimulation provides a key gateway for regulating organ homeostasis.

Publication types

  • Comment

MeSH terms

  • Cell Adhesion Molecules
  • Colitis*
  • Endothelium
  • Humans
  • Mucoproteins*
  • Neuroimmunomodulation

Substances

  • Cell Adhesion Molecules
  • Mucoproteins