Exercise interventions in patients with cirrhosis have been shown to improve muscle mass and strength, aerobic capacity, fatigue, and quality of life. There are gaps, however, including limited data on patients with decompensated cirrhosis and home-based routines. This editorial comments on the randomized controlled trial by Lai et al. investigating a home-based exercise intervention in patients with cirrhosis and its impact on physical frailty. Although the trial yielded negative results, the lessons learned should help refine and propel future work.