1 1Department of Bioinformatics, School of Basic Medicine, Chongqing Medical University, Chongqing, China; 2Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; 3Geneplus-Beijing Institute, Beijing, China; 4Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.