Electrospun polycaprolactone/hydroxyapatite/ZnO films as potential biomaterials for application in bone-tendon interface repair

Xi He; Zongwang Huang; Wenbin Liu; Yanling Liu; Hu Qian; Ting Lei; Long Hua; Yihe Hu; Yi Zhang; Pengfei Lei

doi:10.1016/j.colsurfb.2021.111825

Electrospun polycaprolactone/hydroxyapatite/ZnO films as potential biomaterials for application in bone-tendon interface repair

Colloids Surf B Biointerfaces. 2021 Aug:204:111825. doi: 10.1016/j.colsurfb.2021.111825. Epub 2021 May 12.

Authors

Xi He¹, Zongwang Huang², Wenbin Liu³, Yanling Liu⁴, Hu Qian³, Ting Lei³, Long Hua³, Yihe Hu⁵, Yi Zhang⁶, Pengfei Lei⁷

Affiliations

¹ Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, 410078, China; Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, 410078, China.
² Department of Inorganic Materials, School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, China.
³ Department of Orthopaedical Surgery, Xiangya Hospital, Central South University, Changsha, 410078, China; Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, 410078, China.
⁴ Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease, Department of Urology, Xiangya Hospital, Central South University, Changsha, 410078, China.
⁵ Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, 410078, China; Department of Orthopaedical Surgery, Xiangya Hospital, Central South University, Changsha, 410078, China; Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, 410078, China. Electronic address: [email protected].
⁶ Department of Inorganic Materials, School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, China. Electronic address: [email protected].
⁷ Department of Orthopaedical Surgery, Xiangya Hospital, Central South University, Changsha, 410078, China; Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, 410078, China. Electronic address: [email protected].

PMID: 33984615
DOI: 10.1016/j.colsurfb.2021.111825

Abstract

The bone-tendon interface (BTI) is a graded structure consisting of bone, mineralized and nonmineralized fibrocartilage, and tendons. Due to the complexity of the BTI structure, BTI healing is particularly challenging. To achieve a better material for BTI healing, polycaprolactone (PCL)/hydroxyapatite (HA)/ZnO films were constructed by the electrospinning method; in addition, the relevant material characteristics were tested. After culturing MC3T-E1 cells, ATDC5 cells, mouse primary fibrochondrocytes, and mouse primary tenocytes on films, PCL-5%HA-1%ZnO films (HA and ZnO weight ratios of 5% and 1%, respectively) displayed superior cell compatibility and cell adhesion. PCL-5%HA-1%ZnO films also promoted osteogenesis, chondrogenesis, fibrocartilage formation, and tendon healing. The antibacterial characteristics of PCL-5%HA-1%ZnO films were also identified in this study. The PCL-5%HA-1%ZnO films have great application potential in the field of BTI repair.

Keywords: Antibacterial; Bone-tendon healing; Polycaprolactone; ZnO.

MeSH terms

Animals
Biocompatible Materials / pharmacology
Durapatite*
Mice
Polyesters
Tendons
Tissue Scaffolds
Zinc Oxide*

Substances

Biocompatible Materials
Polyesters
polycaprolactone
Durapatite
Zinc Oxide