Abstract
Epstein-Barr virus infection is the most common viral latent infection in humans and represents one prototypical model to study immunity to viral infections. In that respect, inborn errors of immunity (IEIs) or primary immunodeficiencies (PIDs) predisposing to severe and chronic EBV infections provide peculiar examples to decipher-specific molecular and cellular components involved in the immune control of EBV-infected cells. Herein, we discuss the recent knowledge and concepts arising from these studies, with a particular focus on 'atypical' EBV infections when EBV enters T, NK and smooth muscle cells, instead of the common 'typical' infection of B cells.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
B-Lymphocytes / immunology
-
B-Lymphocytes / metabolism
-
B-Lymphocytes / virology
-
Biomarkers
-
CD8-Positive T-Lymphocytes / immunology
-
CD8-Positive T-Lymphocytes / metabolism
-
Cell Communication
-
Disease Susceptibility / immunology*
-
Epstein-Barr Virus Infections / diagnosis
-
Epstein-Barr Virus Infections / genetics
-
Epstein-Barr Virus Infections / immunology*
-
Epstein-Barr Virus Infections / virology
-
Genetic Predisposition to Disease
-
Herpesvirus 4, Human / immunology*
-
Host-Pathogen Interactions / genetics
-
Host-Pathogen Interactions / immunology*
-
Humans
-
Immunity* / genetics
-
Organ Specificity / immunology
-
T-Lymphocyte Subsets / immunology
-
T-Lymphocyte Subsets / metabolism