Plasma S1P (Sphingosine-1-Phosphate) Links to Hypertension and Biomarkers of Inflammation and Cardiovascular Disease: Findings From a Translational Investigation

Amra Jujic; Frank Matthes; Lotte Vanherle; Henning Petzka; Marju Orho-Melander; Peter M Nilsson; Martin Magnusson; Anja Meissner

doi:10.1161/HYPERTENSIONAHA.120.17379

Plasma S1P (Sphingosine-1-Phosphate) Links to Hypertension and Biomarkers of Inflammation and Cardiovascular Disease: Findings From a Translational Investigation

Hypertension. 2021 Jul;78(1):195-209. doi: 10.1161/HYPERTENSIONAHA.120.17379. Epub 2021 May 17.

Authors

Amra Jujic^#^{1

2

3}, Frank Matthes^#^{2

4}, Lotte Vanherle^{2

4}, Henning Petzka⁵, Marju Orho-Melander¹, Peter M Nilsson^{1

6}, Martin Magnusson^{1

2

7

8}, Anja Meissner^{1

4}

Affiliations

¹ Department of Clinical Sciences (A.J., M.O.-M., P.M.N., M.M.), Lund University, Malmö, Sweden.
² Wallenberg Centre for Molecular Medicine (A.J., F.M., L.V., M.M., A.M.), Lund University, Malmö, Sweden.
³ Lund University Diabetes Centre (A.J.), Lund University, Malmö, Sweden.
⁴ Department of Experimental Medical Sciences (F.M., L.V., A.M.), Lund University, Malmö, Sweden.
⁵ Department of Mathematics, Lund Technical University, Sweden (H.P.).
⁶ Department of Internal Medicine, Clinical Research Unit, Malmö, Sweden (P.M.N.).
⁷ Hypertension in Africa Research Team, North West University Potchefstroom, South Africa (M.M.).
⁸ Department of Cardiology, Skåne University Hospital, Malmö, Sweden (M.M.).

^# Contributed equally.

PMID: 33993723
DOI: 10.1161/HYPERTENSIONAHA.120.17379

Abstract

[Figure: see text].

Keywords: biomarkers; blood pressure; cardiovascular disease; inflammation; sphingosine-1-phosphate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Animals
Biomarkers / blood
Biomarkers / metabolism*
Cardiovascular Diseases / diagnosis
Cardiovascular Diseases / metabolism*
Female
Humans
Hypertension / blood
Hypertension / diagnosis
Hypertension / metabolism*
Inflammation / diagnosis
Inflammation / metabolism*
Logistic Models
Lysophospholipids / blood*
Male
Mice
Mice, Inbred C57BL
Middle Aged
Proteome / metabolism
Proteomics / methods
Sphingosine / analogs & derivatives*
Sphingosine / blood
Translational Research, Biomedical / methods
Translational Research, Biomedical / statistics & numerical data

Substances

Biomarkers
Lysophospholipids
Proteome
sphingosine 1-phosphate
Sphingosine