Nordic guidelines 2021 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms

Eva Tiensuu Janson; Ulrich Knigge; Gitte Dam; Birgitte Federspiel; Henning Grønbaek; Peter Stålberg; Seppo W Langer; Andreas Kjaer; Johanna Arola; Camilla Schalin-Jäntti; Anders Sundin; Staffan Welin; Espen Thiis-Evensen; Halfdan Sorbye

doi:10.1080/0284186X.2021.1921262

Nordic guidelines 2021 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms

Acta Oncol. 2021 Jul;60(7):931-941. doi: 10.1080/0284186X.2021.1921262. Epub 2021 May 17.

Authors

Eva Tiensuu Janson¹, Ulrich Knigge², Gitte Dam³, Birgitte Federspiel⁴, Henning Grønbaek³, Peter Stålberg⁵, Seppo W Langer^{6

7}, Andreas Kjaer^{8

9}, Johanna Arola¹⁰, Camilla Schalin-Jäntti¹¹, Anders Sundin¹², Staffan Welin¹, Espen Thiis-Evensen¹³, Halfdan Sorbye^{14

15}

Affiliations

¹ Department of Medical Sciences, Endocrine Oncology Uppsala University, Uppsala, Sweden.
² Departments of Surgery C and Endocrinology PE, Faculty of Health Science, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
³ Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
⁴ Department of Pathology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁵ Department of Surgical Sciences, Endocrine Surgery, Uppsala University, Uppsala, Sweden.
⁶ Department of Oncology, Rigshospitalet, Copenhagen, Denmark.
⁷ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
⁸ Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, Copenhagen, Denmark.
⁹ Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
¹⁰ Department of Pathology, HUSLAB, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.
¹¹ Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹² Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
¹³ Department for Organ Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
¹⁴ Department of Oncology, Haukeland University Hospital, Bergen, Norway.
¹⁵ Department of Clinical Medicine, University of Bergen, Bergen, Norway.

PMID: 33999752
DOI: 10.1080/0284186X.2021.1921262

Abstract

Background: The diagnostic work-up and treatment of patients with gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) has undergone major advances and new methods are introduced. Furthermore, an update of the WHO classification has resulted in a new nomenclature for GEP-NEN that is implemented in the clinic.

Aim: These Nordic guidelines summarise the Nordic Neuroendocrine Tumour Group's current view on how to diagnose and treat GEP-NEN patients and aims to be useful in the daily practice for clinicians.

Keywords: ;; Diagnosis; neuroendocrine carcinoma; neuroendocrine tumour; treatment.

MeSH terms

Gastrointestinal Neoplasms*
Humans
Intestinal Neoplasms* / diagnosis
Intestinal Neoplasms* / drug therapy
Neuroendocrine Tumors* / diagnosis
Neuroendocrine Tumors* / therapy
Pancreatic Neoplasms* / diagnosis
Pancreatic Neoplasms* / therapy
Stomach Neoplasms* / diagnosis
Stomach Neoplasms* / therapy