Induction of the PPARγ (Peroxisome Proliferator-Activated Receptor γ)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta

Hypertension. 2021 Jul;78(1):230-240. doi: 10.1161/HYPERTENSIONAHA.121.17267. Epub 2021 May 24.

Abstract

[Figure: see text].

Keywords: arteries; placenta; preeclampsia; pregnancy; stillbirth; trophoblast.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzamides / pharmacology
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Female
  • Gene Expression / drug effects
  • Humans
  • PPAR gamma / agonists
  • PPAR gamma / antagonists & inhibitors
  • PPAR gamma / metabolism*
  • Placenta / drug effects
  • Placenta / metabolism*
  • Pre-Eclampsia / genetics
  • Pre-Eclampsia / metabolism*
  • Pregnancy
  • Pyridines / pharmacology
  • RNA Interference
  • Rosiglitazone / pharmacology
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Trophoblasts / cytology
  • Trophoblasts / metabolism
  • Vascular Endothelial Growth Factor Receptor-1 / genetics
  • Vascular Endothelial Growth Factor Receptor-1 / metabolism*

Substances

  • Benzamides
  • DNA-Binding Proteins
  • GCM1 protein, human
  • PPAR gamma
  • Pyridines
  • T 0070907
  • Transcription Factors
  • Rosiglitazone
  • FLT1 protein, human
  • Vascular Endothelial Growth Factor Receptor-1