Small Intestinalization of Colon Using Ileum Organoids

Jinjian Huang; Ziyan Xu; Jianan Ren

doi:10.1016/j.tcb.2021.05.002

Small Intestinalization of Colon Using Ileum Organoids

Trends Cell Biol. 2021 Jul;31(7):517-519. doi: 10.1016/j.tcb.2021.05.002. Epub 2021 May 20.

Authors

Jinjian Huang¹, Ziyan Xu¹, Jianan Ren²

Affiliations

¹ Research Institute of General Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing, China 210009.
² Research Institute of General Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing, China 210009. Electronic address: [email protected].

PMID: 34024728
DOI: 10.1016/j.tcb.2021.05.002

Abstract

Given the mismatch in size and morphology of intestinal organoids with native intestine, their application in intestinal segment regeneration has yet to be achieved. By engrafting ileal organoids in epithelium-removed colon, Sugimoto et al. recently constructed transplantable colonic segments with functional ileal epithelium and a subepithelial lymphovascular system, providing hope for the treatment of short bowel syndrome.

Keywords: intestinal organoids; short bowel syndrome; small intestinal regeneration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Colon
Humans
Ileum
Intestinal Mucosa
Organoids*
Short Bowel Syndrome*