Arcanobacterium haemolyticum can cause deep infections, including osteomyelitis. In this study, an automated system misidentified this causal agent as Cellulomonas species but 16 s rRNA sequencing correctly identified it as A. haemolyticum. Recognizing the capability of A. haemolyticum to establish the disease is of great importance to enable accurate diagnosis and begin the suitable antibiotic therapy. Here we present the first case of successfully treated A. haemolyticum infective osteomyelitis in a 64-year-old Saudi patient with diabetes mellitus type 2 and review the characteristics of this seldom pathogenic agent.
Keywords: 16s rRNA; AMR, anti microbial resistance; AQ20, alignment quality; Arcanobacterium haemolyticum; CARD, the comprehensive antibiotic resistance database; CDS, coding sequence; Cellulitis; Diabetic foot ulcer; EUCAST, The European Committee on Antimicrobial Susceptibility Testing; ISPs, ion sphere particles; Ion PGM, ion personal genome machine; MUSCLE, multiple sequence comparison by log- expectation; NCBI, National Center for Biotechnology Information; NDARO, national database of antibiotic resistant organisms; Osteomyelitis; PATRIC, the Pathosystems Resource Integration Center; Q20, base call quality; RASTtk, rapid annotation using subsystem technology tool kit; RAxML, randomized axelerated maximum likelihood; Whole-genome sequencing and annotation.
© 2021 The Authors.