Macrophage Activation Syndrome in a Child with Juvenile Idiopathic Arthritis Secondary to SARS-CoV-2

Hacer Akturk; Murat Tanyildiz; Fatih Erbey; Mehmet Tasdemir; Aydın Celikyurt; Emel Gonen; Ilmay Bilge

doi:10.1093/tropej/fmab049

Macrophage Activation Syndrome in a Child with Juvenile Idiopathic Arthritis Secondary to SARS-CoV-2

J Trop Pediatr. 2021 May 17;67(2):fmab049. doi: 10.1093/tropej/fmab049.

Authors

Hacer Akturk¹, Murat Tanyildiz², Fatih Erbey³, Mehmet Tasdemir⁴, Aydın Celikyurt⁵, Emel Gonen⁶, Ilmay Bilge⁷

Affiliations

¹ Department of Pediatrics, Pediatric Infectious Disease Unit, Koc University Hospital, Istanbul, Turkey.
² Department of Pediatrics, Pediatric Intensive Care Unit, Koc University Hospital, Istanbul, Turkey.
³ Department of Pediatrics, Pediatric Hematology & Oncology Unit, Koc University Hospital, Istanbul, Turkey.
⁴ Department of Pediatrics, Pediatric Nephrology Unit, Koc University Hospital, Istanbul, Turkey.
⁵ Department of Pediatrics, Koc University Hospital, Istanbul, Turkey.
⁶ Department of Orthopedics, Koc University Hospital, Istanbul, Turkey.
⁷ Department of Pediatrics, Pediatric Rheumotology Unit, Koc University Hospital, Istanbul, Turkey.

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a pandemic affecting many countries and millions of people. Physicians have encountered some rare and challenging cases related to SARS-CoV-2, a novel virus with still many unknowns. In order to share our experience of a such clinical picture, we present here a child with SARS-CoV-2-induced macrophage activation syndrome in the setting of juvenile idiopathic arthritis.

Keywords: juvenile idiopathic arthritis (JIA); macrophage activation syndrome (MAS); secondary haemophagocytic lymphohistocytosis (sHLH); severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

MeSH terms

Arthritis, Juvenile* / complications
COVID-19*
Child
Humans
Macrophage Activation Syndrome* / diagnosis
Macrophage Activation Syndrome* / etiology
Pandemics
SARS-CoV-2