Identification of prognostic tumor-infiltrating immune cells in endometrial adenocarcinoma

Medicine (Baltimore). 2021 May 28;100(21):e26170. doi: 10.1097/MD.0000000000026170.

Abstract

To identify prognostic tumor-infiltrating immune cells of endometrial adenocarcinoma.The gene expression profiles of endometrial adenocarcinoma were downloaded from the Cancer Genome Atlas (TCGA). The abundance of tumor-infiltrating immune cells in endometrial adenocarcinoma samples was calculated by CIBERSORT algorithm. Kaplan-Meier analysis was used to identify prognostic tumor-infiltrating immune cells.This study identified 22 kinds of tumor-infiltrating immune cells. Macrophages M0 and CD8 T cells were prognostic factors of endometrial adenocarcinoma. The abundance of macrophages M0 (P = .038) was significantly correlated with better prognosis of endometrial adenocarcinoma. In contrast, the abundance of CD8 T cells (P = .049) was associated with poor prognosis of endometrial adenocarcinoma.Tumor-infiltrati macrophages M0 and CD8 T cells were prognostic factors of endometrial adenocarcinoma.

MeSH terms

  • Adenocarcinoma / immunology*
  • Algorithms
  • CD8-Positive T-Lymphocytes / immunology*
  • Endometrial Neoplasms / immunology*
  • Female
  • Gene Expression Profiling
  • Humans
  • Kaplan-Meier Estimate
  • Lymphocytes, Tumor-Infiltrating / immunology*
  • Macrophages / immunology*
  • Prognosis
  • Tumor Microenvironment