Abstract
We report 16 orthopaedic patients who had antibiotic-associated diarrhoea (pseudomembranous colitis) after operation. There was an association with the use of cephradine and with the prolongation of prophylaxis for more than three peri-operative doses. Five cases occurred as a cluster, suggesting that the causative agent, Clostridium difficile, may be infectious in some situations.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Cefuroxime / adverse effects
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Cefuroxime / therapeutic use
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Cephalosporins / adverse effects*
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Cephradine / adverse effects*
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Cephradine / therapeutic use
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Enterocolitis, Pseudomembranous / etiology*
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Female
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Humans
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Male
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Middle Aged
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Orthopedics*
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Postoperative Complications*
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Premedication / adverse effects*
Substances
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Cephalosporins
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Cephradine
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Cefuroxime