Abstract
SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.
MeSH terms
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Antibodies, Neutralizing / immunology*
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Antibody Affinity / genetics*
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Antibody Affinity / immunology
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Cross Reactions / genetics
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Immune Evasion / genetics*
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Models, Molecular
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Protein Domains
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SARS-CoV-2 / genetics
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SARS-CoV-2 / immunology*
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Spike Glycoprotein, Coronavirus / chemistry
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Spike Glycoprotein, Coronavirus / genetics
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Spike Glycoprotein, Coronavirus / immunology
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Static Electricity
Substances
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Antibodies, Neutralizing
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Spike Glycoprotein, Coronavirus
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spike protein, SARS-CoV-2