Cardiac computed tomography-derived extracellular volume fraction in late anthracycline-induced cardiotoxicity

Koichi Egashira; Daisuke Sueta; Mai Tomiguchi; Masafumi Kidoh; Seitaro Oda; Hiroki Usuku; Kaori Hidaka; Lisa Goto-Yamaguchi; Aiko Sueta; Takashi Komorita; Masafumi Takae; Fumi Oike; Koichiro Fujisue; Eiichiro Yamamoto; Shinsuke Hanatani; Seiji Takashio; Yuichiro Arima; Satoshi Araki; Koichi Kaikita; Kenichi Matsushita; Yutaka Yamamoto; Toshinori Hirai; Kenichi Tsujita

doi:10.1016/j.ijcha.2021.100797

Cardiac computed tomography-derived extracellular volume fraction in late anthracycline-induced cardiotoxicity

Int J Cardiol Heart Vasc. 2021 May 18:34:100797. doi: 10.1016/j.ijcha.2021.100797. eCollection 2021 Jun.

Authors

Koichi Egashira^{1

2}, Daisuke Sueta^{1

2}, Mai Tomiguchi³, Masafumi Kidoh⁴, Seitaro Oda⁴, Hiroki Usuku^{1

2

5}, Kaori Hidaka³, Lisa Goto-Yamaguchi³, Aiko Sueta³, Takashi Komorita^{1

2}, Masafumi Takae^{1

2}, Fumi Oike^{1

2}, Koichiro Fujisue^{1

2}, Eiichiro Yamamoto^{1

2}, Shinsuke Hanatani^{1

2}, Seiji Takashio^{1

2}, Yuichiro Arima^{1

2}, Satoshi Araki^{1

2}, Koichi Kaikita^{1

2}, Kenichi Matsushita^{1

2

6}, Yutaka Yamamoto³, Toshinori Hirai⁴, Kenichi Tsujita^{1

2}

Affiliations

¹ Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan.
² Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan.
³ Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto, Japan.
⁴ Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto, Japan.
⁵ Department of Laboratory Medicine, Kumamoto University Hospital, Kumamoto, Japan.
⁶ Division of Advanced Cardiovascular Therapeutics, Kumamoto University Hospital, Kumamoto, Japan.

Abstract

Cardiotoxicity in the late phase after anthracycline drugs administration remains to be defined. Of the 44 patients who received anthracycline treatment, 7 were found to have cancer therapeutics-related cardiac dysfunction (CTRCD). The global longitudinal strain determined by echocardiography and myocardial extracellular volume fraction (ECV) determined by cardiac computed tomography (CCT) of the CTRCD(+) group were significantly higher than those of the control group and CTRCD(-) group, whereas there were no significant differences between the control and CTRCD(-) groups. Our findings indicated that CCT may be a tool comparable to echocardiography, indicating the effective evaluation of CTRCD by CCT.

Keywords: Anthracycline; Cardiac computed tomography; Cardio-oncology; Cardiotoxicity.