Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

Joshua J Woods; Madison X Rodriguez; Chen-Wei Tsai; Ming-Feng Tsai; Justin J Wilson

doi:10.1039/d1cc01623g

Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

Chem Commun (Camb). 2021 Jun 22;57(50):6161-6164. doi: 10.1039/d1cc01623g.

Authors

Joshua J Woods¹, Madison X Rodriguez², Chen-Wei Tsai², Ming-Feng Tsai², Justin J Wilson³

Affiliations

¹ Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA. [email protected] and Robert F. Smith School for Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.
² Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³ Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA. [email protected].

Abstract

We report our investigation into the MCU-inhibitory activity of Co3+ complexes in comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar potency. Mutagenesis studies and molecular docking simulations suggest that the complexes operate through interactions with the DIME motif of the MCU pore.

MeSH terms

Amines / chemistry
Amines / pharmacology*
Calcium Channels / metabolism*
Cobalt / chemistry
Cobalt / pharmacology*
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
HEK293 Cells
HeLa Cells
Humans
Molecular Conformation
Molecular Docking Simulation

Substances

Amines
Calcium Channels
Coordination Complexes
mitochondrial calcium uniporter
Cobalt

Abstract

MeSH terms

Substances

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