Would it have happened without Christmas? Thoracic emphysema and allergic bronchopulmonary aspergillosis in a juvenile cystic fibrosis patient with the G551D mutation receiving ivacaftor

Jochen G Mainz; Nina Erdmann; Franziska Duckstein; Carlos Zagoya

doi:10.1183/23120541.00758-2020

Would it have happened without Christmas? Thoracic emphysema and allergic bronchopulmonary aspergillosis in a juvenile cystic fibrosis patient with the G551D mutation receiving ivacaftor

ERJ Open Res. 2021 May 24;7(2):00758-2020. doi: 10.1183/23120541.00758-2020. eCollection 2021 Apr.

Authors

Jochen G Mainz^{1

2

3}, Nina Erdmann¹, Franziska Duckstein¹, Carlos Zagoya¹

Affiliations

¹ Cystic Fibrosis Center, Brandenburg Medical School (MHB) University, Klinikum Westbrandenburg, Brandenburg an der Havel, Germany.
² CF Center, Jena University Hospital, Jena, Germany.
³ Faculty of Health Sciences, joint Faculty of the Brandenburg University of Technology Cottbus-Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam, Germany.

Abstract

Potent CFTR modulators improve CF manifestations far beyond expectations, including reduction of risk of typical complications. This is the first report of a patient who developed life-threatening ABPA and emphysema after overwhelming improvement. https://bit.ly/2P96PTy.