The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ISSCR subcommittee that drafted these guidelines for research involving the use of nonhuman embryos and postnatal animals explains and summarizes their recommendations.
Keywords: ISSCR guidelines; animal research; chimeric embryos; stem cell chimeras.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.