ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts

Stem Cell Reports. 2021 Jun 8;16(6):1409-1415. doi: 10.1016/j.stemcr.2021.05.005. Epub 2021 May 27.

Abstract

The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ISSCR subcommittee that drafted these guidelines for research involving the use of nonhuman embryos and postnatal animals explains and summarizes their recommendations.

Keywords: ISSCR guidelines; animal research; chimeric embryos; stem cell chimeras.

Publication types

  • Review

MeSH terms

  • Animals
  • Chimera*
  • Embryo Research / ethics*
  • Humans
  • Pluripotent Stem Cells*
  • Practice Guidelines as Topic*
  • Societies, Scientific / ethics
  • Societies, Scientific / standards*
  • Stem Cell Research / ethics*
  • Stem Cell Transplantation / ethics
  • Stem Cell Transplantation / standards*