Intensified antibody response elicited by boost suggests immune memory in individuals administered two doses of SARS-CoV-2 inactivated vaccine

Yun Liao; Ying Zhang; Heng Zhao; Jing Pu; Zhimei Zhao; Dandan Li; Shengtao Fan; Li Yu; Xingli Xu; Lichun Wang; Guorun Jiang; Longding Liu; Qihan Li

doi:10.1080/22221751.2021.1937328

Intensified antibody response elicited by boost suggests immune memory in individuals administered two doses of SARS-CoV-2 inactivated vaccine

Emerg Microbes Infect. 2021 Dec;10(1):1112-1115. doi: 10.1080/22221751.2021.1937328.

Authors

Yun Liao¹, Ying Zhang¹, Heng Zhao¹, Jing Pu¹, Zhimei Zhao¹, Dandan Li¹, Shengtao Fan¹, Li Yu¹, Xingli Xu¹, Lichun Wang¹, Guorun Jiang¹, Longding Liu¹, Qihan Li¹

Affiliation

¹ Institute of Medical Biology, Chinese Academy of Medicine Sciences and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development for Severe Infectious Diseases, Kunming, People's Republic of China.

Abstract

Neutralizing antibodies in the subjects of an inactivated SARS-CoV-2 vaccine clinical trial showed a decreasing trend over months. An investigation studying the third immunization suggested that the waning of neutralizing antibodies in individuals administered two doses of inactivated vaccine does not mean the disappearance of immunity.

Keywords: COVID-19; SARS-CoV-2; antibody waning; immune memory; inactivated vaccine.

Publication types

Letter

MeSH terms

Adolescent
Adult
Antibodies, Neutralizing / immunology
Antibodies, Viral / immunology*
COVID-19 / prevention & control*
COVID-19 Vaccines / administration & dosage
COVID-19 Vaccines / immunology*
Humans
Immunization, Secondary*
Immunologic Memory*
Middle Aged
Vaccination / statistics & numerical data
Vaccines, Inactivated / administration & dosage
Vaccines, Inactivated / immunology
Young Adult

Substances

Antibodies, Neutralizing
Antibodies, Viral
COVID-19 Vaccines
Vaccines, Inactivated

Grants and funding

This work was supported by Applied Basic Research Key Project of Yunnan: [Grant Number 202003AC100003,202003AC100009]; The National Key Research and Development Program of China: [Grant Number 2020YFC0849700,2020YFC0860600]; the Program of Chinese Academy of Medicine Science: [Grant Number 2020-I2M-2-014,2020HY320001].