Advances in Technologies for Highly Active Omega-3 Fatty Acids from Krill Oil: Clinical Applications

Mar Drugs. 2021 May 26;19(6):306. doi: 10.3390/md19060306.

Abstract

Euphausia superba, commonly known as krill, is a small marine crustacean from the Antarctic Ocean that plays an important role in the marine ecosystem, serving as feed for most fish. It is a known source of highly bioavailable omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid). In preclinical studies, krill oil showed metabolic, anti-inflammatory, neuroprotective and chemo preventive effects, while in clinical trials it showed significant metabolic, vascular and ergogenic actions. Solvent extraction is the most conventional method to obtain krill oil. However, different solvents must be used to extract all lipids from krill because of the diversity of the polarities of the lipid compounds in the biomass. This review aims to provide an overview of the chemical composition, bioavailability and bioaccessibility of krill oil, as well as the mechanisms of action, classic and non-conventional extraction techniques, health benefits and current applications of this marine crustacean.

Keywords: bioavailability; dietary supplements; krill oil; nutraceuticals; omega-3 polyunsaturated fatty acids.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents* / pharmacokinetics
  • Anti-Inflammatory Agents* / pharmacology
  • Anti-Inflammatory Agents* / therapeutic use
  • Antineoplastic Agents* / pharmacokinetics
  • Antineoplastic Agents* / pharmacology
  • Antineoplastic Agents* / therapeutic use
  • Dietary Supplements*
  • Euphausiacea*
  • Exercise
  • Fatty Acids, Omega-3* / pharmacokinetics
  • Fatty Acids, Omega-3* / pharmacology
  • Fatty Acids, Omega-3* / therapeutic use
  • Fish Oils / chemistry*
  • Fish Oils / pharmacology
  • Gastrointestinal Microbiome / drug effects
  • Humans
  • Inflammatory Bowel Diseases / diet therapy
  • Inflammatory Bowel Diseases / prevention & control
  • Metabolic Diseases / diet therapy
  • Metabolic Diseases / prevention & control
  • Neuroprotective Agents* / pharmacokinetics
  • Neuroprotective Agents* / pharmacology
  • Neuroprotective Agents* / therapeutic use

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Fatty Acids, Omega-3
  • Fish Oils
  • Neuroprotective Agents