Synthetic Fibrin-Derived Bβ15-42 Peptide Delays Thrombus Resolution in a Mouse Model

Arterioscler Thromb Vasc Biol. 2021 Jul;41(7):2168-2180. doi: 10.1161/ATVBAHA.121.316404. Epub 2021 Jun 3.

Abstract

[Figure: see text].

Keywords: macrophages; microvessels; monocyte; plasma; venous thrombosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • Blood Coagulation / drug effects*
  • Cadherins / metabolism
  • Case-Control Studies
  • Coculture Techniques
  • Disease Models, Animal
  • Female
  • Fibrin Fibrinogen Degradation Products / pharmacology*
  • Humans
  • Leukocytes / drug effects*
  • Leukocytes / metabolism
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Peptide Fragments / blood
  • Peptide Fragments / pharmacology*
  • Pulmonary Embolism / blood
  • THP-1 Cells
  • Time Factors
  • Transendothelial and Transepithelial Migration / drug effects*
  • Vena Cava, Inferior / metabolism*
  • Vena Cava, Inferior / pathology
  • Venous Thrombosis / blood*
  • Venous Thrombosis / pathology

Substances

  • Antigens, CD
  • Cadherins
  • Fibrin Fibrinogen Degradation Products
  • Peptide Fragments
  • cadherin 5
  • fibrinogen Bbeta (15-42)