Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state

Hui Wang; Le Yu; Yuan-Jun Qin; Ming Chen; Xin Wang; Huo-Qing Luo; Pei-Lin Cong; Xiao-Li Wang; Hong-Miao Cai; Ai-Lian Zhang; Juan-Guo; Xiao-Hui Sun; Zhao Li; Ming Xue; Na Sun; Qing-Xiu Wang; Ji Hu

doi:10.1016/j.bbrc.2021.05.079

Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state

Biochem Biophys Res Commun. 2021 Aug 6:565:21-28. doi: 10.1016/j.bbrc.2021.05.079. Epub 2021 Jun 2.

Authors

Hui Wang¹, Le Yu¹, Yuan-Jun Qin¹, Ming Chen², Xin Wang³, Huo-Qing Luo², Pei-Lin Cong⁴, Xiao-Li Wang³, Hong-Miao Cai¹, Ai-Lian Zhang¹, Juan-Guo⁵, Xiao-Hui Sun³, Zhao Li¹, Ming Xue¹, Na Sun¹, Qing-Xiu Wang⁶, Ji Hu⁷

Affiliations

¹ Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
² School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China.
³ Department of Anesthesiology, Shanghai No.9 Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200082, China.
⁴ Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200120, China.
⁵ Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710000, Shaanxi, China.
⁶ Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. Electronic address: [email protected].
⁷ School of Life Science and Technology, Shanghai Tech University, Shanghai, 201210, China. Electronic address: [email protected].

PMID: 34090206
DOI: 10.1016/j.bbrc.2021.05.079

Abstract

Preoperative anxiety is common and often comes with a higher probability of worse recovery. However, the neurological mechanism of the effect of preoperative anxiety on general anesthesia and subsequent awakening remains unknown. In this study, we report an anxious state results in delayed awakening in anxiety model mice from sevoflurane general anesthesia. More profound inhibition of DA neurons in the VTA contributes to delayed awakening. Optogenetic stimulation of VTA DA neurons can reverse the delay. The results indicate that VTA DA neurons may be involved in the delay in awakening from general anesthesia caused by anxiety.

Keywords: Anxiety state; DA neurons; Delayed awakening; General anesthesia; VTA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anesthetics, Inhalation / pharmacology*
Animals
Anxiety / drug therapy*
Dopaminergic Neurons / drug effects*
Female
Mice
Mice, Inbred C57BL
Sevoflurane / pharmacology*
Ventral Tegmental Area / drug effects*

Substances

Anesthetics, Inhalation
Sevoflurane