Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs

Targeting the Microtubule EB1-CLASP2 Complex Modulates Na_V1.5 at Intercalated Discs

Circ Res. 2021 Jul 23;129(3):349-365. doi: 10.1161/CIRCRESAHA.120.318643. Epub 2021 Jun 7.

¹ Department of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
² Department of Pharmacology, University Feinberg School of Medicine, Chicago, IL (M.J., F.P., C.G.V., A.L.G., P.W.B.).
³ Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.Y.C., C.A.M.).
⁴ Division of Cardiology (M.P.-H., M.D.), NYU School of Medicine.
⁵ Department of Cell Biology, Erasmus Medical Centre Rotterdam, The Netherlands (N.Y., N.G.).
⁶ Department of Medical Biology, Amsterdam UMC - location AMC, The Netherlands (M.K., A.O.V.).
⁷ Institute of Pharmacology and Toxicology, Technische Universität Dresden, Germany (K.G.).
⁸ Department of Biochemistry and Pharmacology (E.R.), NYU School of Medicine.
⁹ Université de Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France (F.C., R.R., V.P.).

[Figure: see text].

Keywords: electrophysiology; microscopy; microtubule; myocyte, cardiac; zebrafish.