A 25 year perspective on the evolution and advances in an understanding of the biology, evaluation and treatment of kidney cancer

Urol Oncol. 2021 Sep;39(9):548-560. doi: 10.1016/j.urolonc.2021.04.038. Epub 2021 Jun 4.

Abstract

The diagnosis, evaluation and management of patients with renal cell carcinoma has transformed in the 21st century. Utilizing biological discoveries and technological advances, the field has moved from blunt surgical and largely ineffective medical treatments, to nuanced and fine-tuned approaches based on biology, extent of disease and patient preferences. In this review we will summarize the last 25 years of progress in kidney cancer.

Keywords: Kidney cancer; Molecular biology; Nephrectomy; Renal cell carcinoma; Systemic therapy.

Publication types

  • Historical Article
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Biomedical Research* / history
  • Biomedical Research* / trends
  • Carcinoma, Transitional Cell / diagnosis*
  • Carcinoma, Transitional Cell / history
  • Carcinoma, Transitional Cell / therapy*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Kidney Neoplasms / diagnosis*
  • Kidney Neoplasms / history
  • Kidney Neoplasms / therapy*
  • Time Factors