C21, C22 pregnane glycosides and cytotoxic C27 spriostanol steroids from Asparagus cochinchinesis

Guo-Lei Zhu; Qian Hao; Liu Xing; Xiao-Qin Yang; Si-Da Xie; Ping Zhao; Hai-Zhou Li

doi:10.1016/j.steroids.2021.108874

C₂₁, C₂₂ pregnane glycosides and cytotoxic C₂₇ spriostanol steroids from Asparagus cochinchinesis

Steroids. 2021 Aug:172:108874. doi: 10.1016/j.steroids.2021.108874. Epub 2021 Jun 5.

Authors

Guo-Lei Zhu¹, Qian Hao², Liu Xing², Xiao-Qin Yang³, Si-Da Xie³, Ping Zhao⁴, Hai-Zhou Li⁵

Affiliations

¹ Key Laboratory of State Forestry Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming 650224, People's Republic of China; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People's Republic of China.
² Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People's Republic of China.
³ Key Laboratory of State Forestry Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming 650224, People's Republic of China.
⁴ Key Laboratory of State Forestry Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming 650224, People's Republic of China. Electronic address: [email protected].
⁵ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People's Republic of China. Electronic address: [email protected].

PMID: 34102197
DOI: 10.1016/j.steroids.2021.108874

Abstract

A preliminary chemical investigation on 70% MeOH extract of the roots of Asparagus cochinchinensis resulted in the isolation of nine steroids. These isolates comprised of four new C₂₁ (1-4) and one new pregnane (5) glycosides, and four known C₂₇ (6-9) spirostanol steroids. Their structures were identified via analysis of the spectroscopic data and the results of hydrolytic cleavage. The cytotoxic activities of the compounds were tested toward the human tumor cell line Hela (cervical cancer), and compounds 7 and 8 displayed moderate activity with IC₅₀ values of 35.5 and 39.6 μM, respectively.

Keywords: Asparagus cochinchinensis; C(21) pregnane glycosides; C(22) pregnane glycosides; Cytotoxic steroids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / pharmacology*
Apocynaceae / chemistry*
Cell Proliferation
Female
Glycosides / pharmacology*
Humans
Molecular Structure
Plant Extracts / pharmacology*
Plant Roots / chemistry
Pregnanes / pharmacology*
Steroids / pharmacology*
Uterine Cervical Neoplasms / drug therapy*
Uterine Cervical Neoplasms / pathology

Substances

Antineoplastic Agents, Phytogenic
Glycosides
Plant Extracts
Pregnanes
Steroids
pregnane glycoside