Dendritic cell fate determination revealed by "SISter" assays

Tao Wu; Li Wu

doi:10.1016/j.immuni.2021.05.012

Dendritic cell fate determination revealed by "SISter" assays

Immunity. 2021 Jun 8;54(6):1104-1106. doi: 10.1016/j.immuni.2021.05.012.

Authors

Tao Wu¹, Li Wu²

Affiliations

¹ Institute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China.
² Institute for Immunology and School of Medicine, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Centre for Life Sciences, Beijing 100084, China; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing 100084, China. Electronic address: [email protected].

PMID: 34107268
DOI: 10.1016/j.immuni.2021.05.012

Abstract

Establishing the connection between cell fate and fate-related genes in a single progenitor cell is a challenge. In this issue of Immunity, Tian et al. tackled this challenge by designing SIS-seq and SIS-Skew assays and identified Bcor as a negative regulator for dendritic cell differentiation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Differentiation
Dendritic Cells
Stem Cells*
Transcription Factors*

Substances

Transcription Factors