Biologic therapies have the ability to fundamentally change the management of hearing loss; clinicians need to familiarize themselves with their prospective applications in practice. This article reviews the current application of 4 categories of biological therapeutics-growth factors, apoptosis inhibitors, monoclonal antibodies, and gene therapy-in otology and their potential future directions and applications.
Keywords: Biologics; Gene therapy; Growth factors; Hearing preservation; Tympanic membrane regeneration.
Published by Elsevier Inc.