Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae

J Antimicrob Chemother. 2021 Aug 12;76(9):2302-2305. doi: 10.1093/jac/dkab184.

Abstract

Objectives: To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae.

Methods: MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time-kill analysis.

Results: We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time-kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem.

Conclusions: Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carbapenems* / pharmacology
  • Enterobacteriaceae*
  • Microbial Sensitivity Tests
  • Zidovudine / pharmacology
  • beta-Lactamases

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Zidovudine
  • beta-Lactamases
  • beta-lactamase NDM-1