Mortality in Patients With Genetic and Environmental Risk of Liver Disease

Am J Gastroenterol. 2021 Aug 1;116(8):1741-1745. doi: 10.14309/ajg.0000000000001326.

Abstract

Introduction: The increasing liver-related mortality calls for hepatic surveillance programs. To design them, factors selectively increasing liver-related vs overall mortality need to be identified.

Methods: We analyzed mortality data from 467,558 individuals recruited by the community-based UK Biobank. The mean follow-up was 11.4 years.

Results: While all assessed genetic factors associated with increased liver-specific mortality, only homozygous TM6SF2 mutation and SERPINA1 mutation conferred elevated overall mortality. Among the environmental factors, obesity and metabolic syndrome disproportionately contributed to liver-related deaths.

Discussion: Our data demonstrate an interplay between genetics and environment and provide a basis for hepatic surveillance programs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Liver Diseases / genetics*
  • Liver Diseases / mortality*
  • Male
  • Membrane Proteins
  • Metabolic Syndrome / complications*
  • Middle Aged
  • Obesity / complications*
  • Risk Factors
  • United Kingdom / epidemiology
  • alpha 1-Antitrypsin

Substances

  • Membrane Proteins
  • SERPINA1 protein, human
  • TM6SF2 protein, human
  • alpha 1-Antitrypsin