Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp

Birthe Sandargo; Leon Kaysan; Rémy B Teponno; Christian Richter; Benjarong Thongbai; Frank Surup; Marc Stadler

doi:10.3762/bjoc.17.97

Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp

Beilstein J Org Chem. 2021 Jun 4:17:1385-1391. doi: 10.3762/bjoc.17.97. eCollection 2021.

Authors

Birthe Sandargo¹, Leon Kaysan^{1

2}, Rémy B Teponno^{1

3}, Christian Richter¹, Benjarong Thongbai¹, Frank Surup¹, Marc Stadler^{1

4}

Affiliations

¹ Microbial Drugs Department, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
² Technical University of Ilmenau, 98693 Ilmenau, Germany.
³ Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
⁴ Institute of Microbiology, Technical University of Braunschweig, Germany.

Abstract

A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin (1), fulvoferruginins B-F (2-6). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest.

Keywords: Basidiomycota; Marasmius; antibiotics; carotane; fulvoferruginin; sesquiterpenoid.

Grants and funding

B.S. and F.S. are grateful for financial support from the Deutsche Forschungsgemeinschaft (DFG) for grant SU 936/1-1. The German Academic Exchange Service (DAAD) and the Thai Royal Golden Jubilee-Industry Program (RGJ) for a joint TRF/DAAD PPP (2014-2015) academic exchange grant to M.S. and F.S. and the RGJ for a personal grant to B.T. (No. Ph.D./0138/2553 in 4.S.MF/53/A.3) are also gratefully acknowledged. The Alexander von Humboldt Foundation is acknowledged for its financial support to R.B.T.