Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2

Naasson M Mbenza; Nawal Nasarudin; Praveen G Vadakkedath; Kamal Patel; A Z Ismail; Muhammad Hanif; L James Wright; Vijayalekshmi Sarojini; Christian G Hartinger; Ivanhoe K H Leung

doi:10.1002/cbic.202100181

Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2

Chembiochem. 2021 Aug 3;22(15):2521-2525. doi: 10.1002/cbic.202100181. Epub 2021 Jun 29.

Authors

Naasson M Mbenza^{1

2}, Nawal Nasarudin¹, Praveen G Vadakkedath^{1

3}, Kamal Patel¹, A Z Ismail^{1

4}, Muhammad Hanif^{1

5}, L James Wright¹, Vijayalekshmi Sarojini^{1

3}, Christian G Hartinger^{1

5}, Ivanhoe K H Leung^{1

5

6

7}

Affiliations

¹ School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand.
² School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington, 6140, New Zealand.
³ The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, PO Box 600, Wellington, 6140, New Zealand.
⁴ Department of Chemistry, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
⁵ Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag, 92019, Victoria Street West, Auckland, 1142, New Zealand.
⁶ School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia.
⁷ Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia.

PMID: 34137488
DOI: 10.1002/cbic.202100181

Abstract

Hypoxia-inducible factor prolyl hydroxylase domain 2 (PHD2) is an important oxygen sensor in animals. By using the CO-releasing molecule-2 (CORM-2) as an in situ CO donor, we demonstrate that CO is an inhibitor of PHD2. This report provides further evidence about the emerging role of CO in oxygen sensing and homeostasis.

Keywords: CORM-2; PHD2; carbon monoxide; gasotransmitter; hypoxia-inducible factor alpha.

MeSH terms

Carbon Monoxide* / chemistry
Carbon Monoxide* / metabolism
Carbon Monoxide* / pharmacology
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Humans
Hypoxia-Inducible Factor-Proline Dioxygenases* / antagonists & inhibitors
Hypoxia-Inducible Factor-Proline Dioxygenases* / metabolism
Prolyl-Hydroxylase Inhibitors / chemistry
Prolyl-Hydroxylase Inhibitors / pharmacology

Substances

Hypoxia-Inducible Factor-Proline Dioxygenases
Carbon Monoxide
EGLN1 protein, human
Enzyme Inhibitors
Prolyl-Hydroxylase Inhibitors

Abstract

MeSH terms

Substances

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